Espiritu Santo is the largest island in the nation of Vanuatu, with an area of 3,955.5 km2 (1,527.2 sq mi). It belongs to the archipelago of the New Hebrides in the Pacific region of Melanesia. It is in the Sanma Province of Vanuatu.
The town of Luganville, on Espiritu Santo's southeast coast, is Vanuatu's second-largest settlement and the provincial capital. Roads run north and west from Luganville but most of the island is far from the limited road network.
Vanuatu's highest peak is the 1879 metre (6165 foot) Mount Tabwemasana in west-central Espiritu Santo.
In 1998, Santo hosted the Melanesia Cup.