Misool is one of the four major islands in the Raja Ampat Islands in West Papua (formerly Irian Jaya), Indonesia. Its area is 2,034 km². The highest point is 535 m and the main towns are Waigama, located on the island's northern coast, and Lilinta.
The inhabitants speak the Biga language and Matbat language, as well as Indonesian.
Other main islands of this group off the western end of West Papua are Salawati, Batanta and Waigeo, and there are numerous smaller islands such as Kofiau.